Have a good weekend

Well, the thing that needed to get done finally got done. Maybe I'll escape with my hide intact. I am looking forward to a fun weekend. I hope that you have a great weekend, and see you on Monday.

The impacts of the new EPA rule on methylene chloride to laboratories in the United States

I have been making nervous noises about the EPA ban on methylene chloride, and I believe that my thoughts are confirmed (unbeknownst to me) by the American Chemical Society's comment on the (then proposed) rule (opens PDF, via ACS' Will Hartwig):

ACS appreciates the current proposed rule’s goal of protecting public health. However, ACS is concerned that the current proposal to regulate methylene chloride, also known as dichloromethane (DCM), fails to account for its use in small scale and particularly academic teaching and research laboratories.

Both the EPA (with 40 CFR 262 Subpart K) and OSHA (with 29 CFR 1910.1450) have recognized that regulations aimed at protecting workers in industry do not translate to academic laboratories. As currently structured, the rule would be extremely challenging for academic institutions to implement and would negatively impact research and teaching. The proposed rule is not appropriate for academic laboratories because exposures are low, infrequent, and well managed using existing regulations and engineering controls (e.g. chemical fume hoods)

From my analysis of the new rule, any workplace that uses methylene chloride must:

1. determine and document who uses DCM
2. document and monitor the exposure during usage, which
3. means getting a monitoring device (likely a PID, is my guess, which is a $4000 instrument)*
4. determining and documenting TWAs for each usage and user

(I've read enough comments from industry to understand that the PIDs that are available aren't particularly well suited for this usage, so that's another problem. (page 6, PDF)

I'm not a chemical safety professional, so I could be wrong. But that's my basic read of the new rule, and I think it is matched by the ACS. No professor is going to this - instead, they're going to either 1) ignore the new rule or 2) ban the use of DCM in their labs. Hard to know which one they will choose.

I'd love people's opinions.

Job posting: Principal Scientist, Medicinal Chemistry, San Diego, CA

Via friend of the blog Alex Goldberg, this job posting: 

Principal Scientist, Medicinal Chemistry

The successful candidate will lead lab chemistry efforts in the department enabling projects across the portfolio. They will also utilize the Genesis Therapeutics platform and assist medicinal chemistry efforts in drug discovery programs from Hit ID through candidate nomination. They will collaborate on multidisciplinary drug discovery projects, direct CRO chemists, and be responsible for synthetic chemistry strategy. The candidate will be expected to be a synthetic chemistry leader to drive programs.

Job Responsibilities:

• Formulate and implement synthetic chemistry strategies across a portfolio to drive drug discovery programs from Hit ID through candidate nomination.
• Identify opportunities to improve lab functions through technology, synthetic chemistry, or external resources.
• Utilize the Genesis platform to execute drug discovery programs.
• Use SBDD principles, optimize physiochemical properties, interpret in vitro and in vivo ADME/PK/Toxicology data, and understand in vitro and in vivo biology data to drive programs.
• Work with other drug discovery disciplines (biology, DMPK, software engineers, computational chemists) to drive hypothesis driven decisions, improve the platform and contribute to the scientific excellence of the company.
• Communicate and engage regularly with project team members.
• Interact and direct a team of CRO chemists anywhere in size from 5-20.
• Mentor internal chemists as well as other scientific disciplines on synthetic chemistry strategy.

Education and Experience Requirements:

• PhD in synthetic organic chemistry or medicinal chemistry with at least 6 years of industrial drug discovery experience OR
• MS in synthetic organic chemistry with at least 10 years of industrial drug discovery experience

Full ad here. Best wishes to those interested. 

EPA bans most uses of methylene chloride

Via C&EN, this news: 

The US Environmental Protection Agency has banned most uses of methylene chloride, a solvent that has been linked to a number of adverse health effects and some deaths.

Since 1980, at least 88 people have died from acute exposure to methylene chloride, the agency says. Longer-term exposure can also lead to liver damage and the development of at least six different types of cancers, it adds.

Methylene chloride is the second compound, after asbestos, to be banned under the revised Toxic Substances Control Act. The ban, which follows a risk assessment and an April 2023 proposal, will phase out all consumer uses within a year and most industrial and commercial uses within the next 2 years.

Uses of methylene chloride that are exempt from the ban include as a raw material for producing electric-vehicle batteries and climate-friendly refrigerant chemicals. And methylene chloride can continue to be used as a laboratory chemical.

“For each use of the chemical that will continue, EPA has developed a first-of-its-kind worker protection program, so that the workers who are helping make and use the chemical . . . are protected, as they deserve to be,” Michal Freedhoff, assistant administrator for the EPA’s Office of Chemical Safety and Pollution Prevention, said during a press briefing. Workplaces that are exempt from the ban will have 18 months to put worker protections in place.

Pharmaceutical use isn't covered by TSCA. Here's the finalized rule. I have strong suspicions that the workplace safety requirements are pretty strict, but I'm going to withhold judgment until I read the whole thing, which I haven't.  

The 2024 Chemistry Faculty Jobs List: 554 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 554 research/teaching positions and 86 teaching positions. 

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On May 9, 2023, the 2023 Chemistry Faculty Jobs List had 626 research/teaching positions and 82 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

Job posting: professor of practice, Department of Chemistry, Tulane University, New Orleans, LA

From the inbox: 

The Department of Chemistry at Tulane University invites applications for a Professor of Practice position beginning in the Fall 2024. The successful applicant will have a Ph.D. in Chemistry with expertise in Organic Chemistry. Duties will include supervising General Chemistry Laboratories, which, in total, involves about 17 teaching assistants, and teaching a section of General Chemistry lecture class (~150 students).  The Department of Chemistry recognizes and rewards innovative and quality teaching. Candidates interested in creating and adopting pedagogical innovations will find many opportunities and support to pursue their interests. The successful candidate will have a record of excellent teaching and mentoring at the undergraduate level, and commitment to student-centered teaching and to increasing diversity in chemistry.  

The Professor of Practice appointment is renewable every three years (initially) and every five years after promotion to Senior Professor of Practice. 

Search started on April 22. Full ad here. Best wishes to those interested. 

If a lab accident happened and no one saw it, did it really happen?

In this week's C&EN, this letter to the editor: 

I just had to comment on the two pieces from Newscripts in the April 1 issue of C&EN (page 40). In the first piece, the revelation by Jessica Pomerantz reminded me of an experience I had in 1977 in a senior-level physical chemistry class at Iowa State University. 

It involved a Lewis acid-base reaction of boron trifluoride and trimethylamine in a rather complex glass network that included a liquid-nitrogen cold trap because the reaction was so exothermic. The instructions for valve settings and operation were quite specific and stated that if they were not followed explicitly, the apparatus could explode. I arranged all valves meticulously, or so I thought, and then opened the valve on the BF₃ cylinder, which was connected to the glassware inlet by a rubber hose. Unfortunately, the one valve I forgot to open was the inlet valve to the apparatus. Within seconds, the hose popped off, and I had a fuming ball of BF₃ within 1 ft (0.3 m) or so of my face. I had the presence of mind to shut off the cylinder valve, and then I watched as the fuming cloud, which stayed intact, floated to the ceiling and rolled all the way to the other corner and escaped through a roof vent. It reminded me of the movie The Blob, except this blob rolled along the ceiling and not the floor. My classmates and the teaching assistant were so absorbed in their own work that they did not observe the blob. Nobody at Iowa State ever learned of my slight mistake. I successfully completed the experiment on the second attempt.

This brings me to the second Newscripts article. During my many years in industry and to this day, I have written numerous articles for various technical trade magazines, including Chemical Engineering, Power Engineering, and others. I am now a self-employed technical writer and consultant. From the experience above and several others during my career (such as tripping and falling into several inches of yucky flue gas desulfurization sludge), I can decidedly appreciate the title of the second piece, “And This Is Why We’re Journalists Now.”

Brad Buecker
Lawrence, Kansas

I've had my share of near misses and dumb errors and I'm glad that I can look at them with humor now. 

It is strange to me how laboratory chemical experiments of the past were seemingly so complex compared to the microscale experiments I performed in my undergraduate education in the 1990s. While we certainly generated less waste, I wonder if some of the really cool chemistry was lost to time...

(The answer to the headline is, of course, "yes.")

C&EN: "Dow and BASF post upbeat first-quarter results"

In this week's Chemical and Engineering News, this good news (article by Alex Tullo): 

First-quarter financial results are out from Dow and BASF. And if these two chemical giants are setting the trend for their peers—which are due to report their results over the next several weeks—the industry may be turning the corner after a dismal 2023.

Dow’s sales fell 9.2% from the year-earlier period, while adjusted earnings slipped 5.1%. Sales and prices were down across all its business.

But compared with the fourth quarter of 2023, Dow’s sales and earnings were up 1.4% and 28.8%, respectively. A small decline in its core packaging and specialty plastics segment was more than offset by growth in its industrial intermediates and infrastructure business and its performance materials and coatings unit.

Excess capacity hit the petrochemical industry hard last year, particularly in high-cost regions such as Europe. But Dow CEO Jim Fitterling was upbeat during his April 25 conference call with analysts. “Most of the capacity is in the market already, and we’re seeing volume growth,” he said.

Dow’s own operating rates rose 10% in the first quarter, Fitterling reported. And he said lower-cost locales like the US and the Middle East should perform strongly. “We have been through the worst of it on the slowdown in the cycle,” he added.

BASF announced that it “got off to a solid start in 2024.” Its sales fell 12.2% and its earnings dropped 12.9% from the year-earlier quarter. The company attributes the decline primarily to lower prices. A few key businesses, such as chemicals, materials, nutrition, and personal care, saw improvements in volumes.

I used to think that basic chemical manufacturers' businesses were pro-cyclical (i.e. they do well when the broader economy does well), but the post-pandemic economy feels like that has broken that connection. Here's hoping that this good news means good news for the broader economy as well. 

Have a good weekend

Well, this hasn't been the best week, to be honest. Here's hoping we get things done that need to get done. I hope you have a great weekend. See you on Monday. 

Novartis shifting manufacturing due to threat of BIOSECURE Act

Via FiercePharma, this news: 

As the BIOSECURE Act threatens to upend relationships with Chinese contractors and western biopharma companies operating in the U.S., Novartis has elected not to adopt a “wait and see” attitude.

Novartis, like many drugmakers, has ties to Chinese firms in the manufacturing and contract research space, the Swiss pharma’s CFO, Harry Kirsch, said on a press call Tuesday during its first quarter financial results. Amid the threat of a looming biosecurity crackdown by the U.S. government against many of those Chinese biotechs, Novartis is now “actively” managing the situation, Kirsch said.

“So, by the time this comes into effect, we will have no exposure from our planning,” the CFO explained, adding that the situation will be “mitigated in a very reasonable timeframe.”

Kirsch went on to explain that the company is weighing changes to its contracting relationships with Chinese companies “so that we are fully aligned” with potential U.S. regulations.

Novartis’ decision to cut ties with certain Chinese contractors follows the House Select Committee on the Strategic Competition between the United States and the Chinese Communist Party’s unveiling of the BIOSECURE Act in January.

The bill, which is still subject to further review and modification before it potentially becomes law, aims to keep U.S. taxpayer dollars out of the hands of “foreign adversary biotech companies” that allegedly pose a national security concern.

I'm surprised to hear this, but I guess this indicates that large pharma companies seem to think that the BIOSECURE Act has a solid chance of passing. I'm genuinely skeptical, but we will see. 

Job posting: scientist, discovery chemistry, Merck

Via Twitter, this tweet from Dani Schultz: 

We have multiple openings in Boston, San Francisco and West Point (PA) spanning Bachelor's, Master’s, entry level PhD and PhD with experience. Go to http://jobs.merck.com and search for ‘Discovery Chemistry’ or ‘Peptide’! 

Here's one of the ads for the West Point site: 

Our company is currently seeking passionate synthetic organic or medicinal chemists for positions within the Discovery Chemistry Department located at our West Point, PA site. The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying innovative synthetic chemistry, analytical techniques, and data analysis to design and synthesize drug candidates and intermediates.

Successful candidates must have excellent interpersonal, collaboration, and communication skills in a team environment and a proven record of solving complex problems. Additionally, it is expected that the successful candidate will learn quickly through on-the-job training to become increasingly skilled and independent in reaction setup, route design and optimization.

Specific responsibilities will include:

• Collaborative and independent synthetic route design, execution, and optimization to access assigned target molecules using modern synthetic chemistry techniques
• Selection and application of appropriate purification techniques including flash chromatography, high performance liquid chromatography (HPLC) and recrystallization
• Acquisition and interpretation of analytical data such as NMR and LC/MS

Full ad here. Best wishes to those interested.

You can get drunk without drinking alcohol?

Via the New York Times, I learned about auto-brewery syndrome: 

...In Belgium, the brewery worker — a 40-year-old man who wishes to remain anonymous, according to his lawyer — was pulled over by the police in April 2022 and registered a blood-alcohol reading that was more than four times the legal limit. A month later, he was pulled over again and registered more than three times the limit.

It was the third time the man had been cited — he had been pulled over and fined for driving under the influence in 2019. He was unaware that he had A.B.S. until his latest charge — tests administered by three doctors confirmed that he had the condition and validated his claim in court.

“I think he was somehow relieved that he finally knew what was up,” the man’s lawyer, Anse Ghesquiere, said. Her client is now following a strict diet and receiving medical treatment to avoid flare-ups and manage the condition...

According to this paper, it's cured with anti-fungal medication and a low-sugar diet. To be honest, this doesn't sound very fun. 

The 2024 Chemistry Faculty Jobs List: 552 research/teaching positions and 86 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 552 research/teaching positions and 86 teaching positions. 

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 25, 2023, the 2023 Chemistry Faculty Jobs List had 622 research/teaching positions and 81 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.  

C&EN: Disagreement about the decision to vent and burn the vinyl chloride

In this week's issue of Chemical and Engineering News, this comment: 

Thanks for publishing Priyanka Runwal’s fine article on East Palestine, Ohio, in the Feb. 26, 2024, issue of C&EN (page 24).

The Norfolk Southern train derailment should have received a prompt federal response since the onboard cargo was being used in interstate commerce (from Madison, Illinois, to Conway, Pennsylvania). The State of Ohio did respond to this disaster, but it took some poking and prodding for the state to act.

I spoke to the governor’s representative in my region, who indicated that the state maintains multiple boards and commissions. The State Emergency Response Commission looked like a good choice for active engagement. But membership was limited to elected officials, emergency management personnel, environmental advocates, firefighters, first responders, industry and trade personnel, law enforcement personnel, and utility personnel. Nothing to engage scientists and engineers in this emergency.

The lack of an expert in science and engineering in charge rendered communication of the facts to residents of East Palestine, people in the nearby communities, and those who sought answers to be spotty at best.

It is my considered opinion that the decision to vent and burn the vinyl chloride was made without expert consultation. As Runwal’s piece noted, former American Chemical Society president William Carroll pointed out in a hearing that the polymerization reaction of vinyl chloride to polyvinyl chloride requires an initiator. Free radicals, such as chemicals containing peroxides, can initiate polymerization. I don’t know whether the conditions existed for the polymerization of vinyl chloride to have occurred.

People in the East Palestine region are still suffering from the response to the derailment. The federal government response to East Palestine must not be the norm, and the states should expand the relevant boards and commissions to include scientists and engineers. In events such as East Palestine, the designated scientists and engineers would handle communicating the facts to those in the impacted communities and beyond.

ACS should play a central role in having regional experts available to the state and federal entities needing such guidance. This is a role in which ACS can make a real, quantifiable difference.

Mitigating disasters is important, as are the lives of the people in the impacted areas. While each incident is different, there is nothing more reassuring to the people in the impacted areas than knowing that they have the best available facts (in real time) and that we’ve got their backs.

David M. Manuta, Waverly, Ohio

I'm terribly curious to see what the various agencies report when the ultimately do so... 

Have a great weekend

Well, I was gifted two quiet days this week, and I got half of what I wanted to get done, done. So here's hoping I can get the other half done on Friday. I hope that you got accomplished what you hoped to, and that you have a fantastic weekend. I know I will try to! See you on Monday. 

Would you pay $1500 to be an Japanese steel manufacturing worker?

Via the New York Times, this very fun trip to an ancient Japanese steel foundry: 

...Safety was paramount because around the flames, at various stations, milled a team of some 20 excited tourists, a mix of both Japanese and a few foreigners, all dressed in very hip dark gray jumpsuits. These were people paying roughly ¥200,000, or about $1,500, for the chance to be a worker in a tatara-ba for a day and night. (They would get to keep the jumpsuits and a small piece of raw steel as souvenirs.) Their faces and hands were streaked by charcoal.

Jewel steel is produced by sprinkling iron sand — alluvial (river-deposited) sand saturated with iron — slowly over a charcoal pit. The tourists spent hours chopping the pine charcoal to precise sizes. They used scoops woven from bamboo to gather heaps of charcoal and dump them atop the furnace.

Off to the side stood a man named Noriaki Yasuda. He was the designated conductor — called a murage — of this slow dance between heat, charcoal and dampened iron sand. Dressed in an electric blue jumpsuit, he stood out in beautiful, almost poetic, contrast to the licking orange flames.

Monitoring the airflow, the color of the fire and the height of the charcoal with paternal concern, Mr. Yasuda scowled and watched, sometimes retreating to sit in his dark alcove, his arms crossed, still scowling and watching. To produce steel using the tatara technique, it turns out, you spend a lot of time watching.

I'm delighted (and not surprised) that there is a touch of chemistry: 

...“Steel is just iron with a little bit of carbon,” Mr. Yasuda explained to me. When I finally built up the courage to talk with him, his face lit up in a wide smile from behind his mask. (Everyone was wearing masks, less out of Covid concerns and more because of the charcoal dust.) He casually led me to a blackboard in the back of his resting space and sketched out the basic chemical formulas of what was happening in the furnace, how charcoal serves two purposes. First, it burns much hotter than wood. And second, its carbon atoms are essential to the formation of steel; embedded between iron atoms, they increase the strength of the metal.

First, as someone who works in chemical manufacturing, I'm guessing that we cannot get tourists to pay $1500 to work a shift - more's the pity. It is also interesting how they are careful with the size of the charcoal - makes sense, i.e. more uniform pieces allow for better control of the heat. Fun article - read the whole thing. 

Job posting: chemistry teacher, Regis High School, New York City, NY

Via C&EN Jobs: 

Position Summary

Regis seeks a qualified candidate to join its faculty as a Chemistry Teacher beginning September 2024 for the Academic Year 2024-2025. This is a full-time faculty position. Position comes with full benefits. Work hours may vary and will include some evenings and weekends for special school events. Salary is very competitive for the New York City area and is commensurate with experience. The 2024-2025 school year for faculty members ends on June 13, 2025.

Job Responsibilities

• Supports and Advances the Catholic Jesuit Mission of the School
• Works in collaboration with the administration in observing the principles and ideals for which Regis High School stands for
• Devotes energies to teaching in conformity with the policies of Regis High School and is subject at all times to the general control and supervision of the Principal
• Will perform services that include the preparation of examinations, the correction and assignment of grades, and assigned proctoring
• Responsible for ongoing professional development, the customary conferences with students and parents, individual guidance of students, serving as an academic advisor with a student advisement group, direction of student extracurricular activities, service on faculty committees, active service in studying department and school issues, preparation of syllabi, attendance at events listed in the school’s Faculty Handbook under “Faculty Staff Participation in Key Events,” attendance at faculty meetings, and participation in other such professional incidental services, in the judgment of the Principal, the needs of the school require
• Will be generally available to the students in their assigned department resource room through the school day when not teaching class; further, is to have one hour after school availability weekly, according to a schedule subject to the approval of the Principal

Qualifications & Skills

• Position includes teaching 10th grade chemistry classes
• Position may include working with students in advanced individual science projects in school’s SRP Program (Science Research Program) and may include teaching an advanced chemistry class in the future
• Experience working with adolescents
• Excellent organization and communication skills
• Successful teaching experience (high school or higher education)
• Familiarity with and understanding of practical uses of technology for instruction

Education

• B.S. Degree with a major in Biology or Chemistry is required
• Master's Degree in Biology or Chemistry or a Master of Science in Education is preferred
• Evidence of continuing professional education through conferences, seminars, or professional associations is preferred

Compensation & Benefits

Salary range - $71,660. Commensurate with years of experience and level of success in the institutional advancement area, eligible for most benefits immediately.

Most benefits go into effect immediately. Participation in the 403 (b) occurs after one year of employment.

To Apply:

Interested applicants should submit a cover letter and resume by email to employment@regis.org. Qualified applicants will be contacted regarding next steps once all required documents have been submitted. Applications will be accepted until the position is filled.

Full ad here. Best wishes to those interested. 

The craziest hybrid sheep story you will hear today

Via Twitter and the Department of Justice: 

Defendant Worked to Traffic Marco Polo Sheep Parts from Kyrgyzstan, Clone Sheep, Illegally Inseminate Ewes to Create Hybrids and Traffic Rocky Mountain Bighorn Sheep Parts

A Montana man pleaded guilty today to two felony wildlife crimes – a conspiracy to violate the Lacey Act and substantively violating the Lacey Act – as part of an almost decade-long effort to create giant sheep hybrids in the United States with an aim to sell the species to captive hunting facilities.

Arthur “Jack” Schubarth, 80, of Vaughn, Montana, is the owner and operator of Sun River Enterprises LLC – also known as Schubarth Ranch – which is a 215-acre alternative livestock ranch in Vaughn. The Schubarth Ranch is engaged in the purchase, sale and breeding of “alternative livestock” such as mountain sheep, mountain goats and various ungulates. The primary market for Schubarth’s livestock is captive hunting operations, also known as shooting preserves or game ranches.

According to court documents, Schubarth conspired with at least five other individuals between 2013 and 2021 to create a larger hybrid species of sheep that would garner higher prices from shooting preserves. Schubarth brought parts of the largest sheep in the world, Marco Polo argali sheep (Ovis ammon polii), from Kyrgyzstan into the United States without declaring the importation. Average males can weigh more than 300 pounds with horns that span more than five feet. Marco Polo argali are native to the high elevations of the Pamir region of Central Asia. They are protected internationally by the Convention on International Trade in Endangered Species, domestically by the U.S. Endangered Species Act and are prohibited in the State of Montana to protect native sheep from disease and hybridization.

Schubarth sent genetic material from the argali parts to a lab to create cloned embryos. Schubarth then implanted the embryos in ewes on his ranch, resulting in a single, pure genetic male Marco Polo argali that he named “Montana Mountain King” or MMK.

Court documents explain that Schubarth worked with the other unnamed coconspirators to use MMK’s semen to artificially impregnate various other species of ewes – all of which were prohibited in Montana – and create hybrid animals. Their goal was to create a larger and more valuable species of sheep to sell to captive hunting facilities, primarily in Texas.

Presuming this is true, I can't feel very sorry for Mr. Schubarth. I do wonder if the people who were doing the cloning knew what he was doing, and if they knew it was illicit.  

WuXi in the NYT

There's an article in the New York Times about the BIOSECURE Act, and its impact with WuXi on the general pharmaceutical market. This is the only relevant portion (I feel): 

Last month, after a classified briefing with intelligence staff, the Senate homeland security committee advanced a bill by a vote of 11 to 1: It would bar companies from receiving government contracts for work with Wuxi, but would allow the companies to still obtain contracts for unrelated projects. Government contracts with drugmakers are generally limited, though they were worth billions of dollars in revenue to companies that responded to the Covid-19 pandemic.

The real question is 1) will a bill pass, and 2) what will the bill look like? If the Senate version looks like this (i.e. banning the government from working directly with WuXi, but not stopping pharma companies from working with WuXi), I suspect this is going to not be particularly impactful.

The 2024 Chemistry Faculty Jobs List: 548 research/teaching positions and 84 teaching positions

The 2024 Chemistry Faculty Jobs List (curated by Andrew Spaeth and myself) has 548 research/teaching positions and 82 teaching positions. 

Want to help out? Here's a Google Form to enter positions.

To see trending, go to Andrew Spaeth's visualization of previous years' list.

On April 18, 2023, the 2023 Chemistry Faculty Jobs List had 619 research/teaching positions and 80 teaching-focused positions.

Want to talk anonymously? Have an update on the status of a job search? Here's the first open thread. Here's a link to the second, open thread. Here's a link to the current, third open thread. 

Don't forget to click on "load more" below the comment box for the full thread.